Guide IL-1ra in the Treatment of Rheumatoid Arthritis: pocketbook

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IL discoveries, controversies and future directions. The history of fever, leukocytic pyrogen and interleukin Temperature 2 8— Treating inflammation by blocking interleukin-1 in humans. A cartilage catabolic factor from synovium.

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Detection and characterization of high affinity plasma membrane receptors for human interleukin 1. The fever of gout: urate crystals activate endogenous pyrogen production from human and rabbit mononuclear phagocytes. Physicians 96 — Identification of an interleukin-1 beta binding protein in human plasma. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression.

Interleukin-1 receptor antagonist as therapy for inflammatory disorders. Expert Opin. A candidate gene for familial Mediterranean fever. The interleukin-1 family: back to the future. Immunity 39 — Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process. An interleukin 1 like factor stimulates bone resorption in vitro.

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis. Osteoarthritis Cartilage 19 — Interleukin 1 alpha and interleukin 1 beta bind to the same receptor on T cells.

Two-chain structure of the interleukin 1 receptor.

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Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 32 — Crystal-induced endogenous pyrogen production. A further look at gouty inflammation. Interleukinreceptor antagonist deficiency and generalised pustular psoriasis.

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Cell 10 — Gout-associated uric acid crystals activate the NALP3 inflammasome. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor interleukin 1. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

BMC Med. Inflammasome-independent regulation of ILfamily cytokines. Specific interleukin-1 inhibitor in serum and urine of children with systemic juvenile chronic arthritis.

Advancing Treatment of Rheumatoid Arthritis Video – Brigham and Women’s Hospital

Lancet 2 — Gout as autoinflammatory disease: new mechanisms for more appropriated treatment targets. Serum uric acid and gout: from the past to molecular biology. Crystal-induced neutrophil activation. Differential production of biologically active IL-1 and IL-1 receptor antagonist. Identification of catabolin, a protein from synovium which induces degradation of cartilage in organ culture. Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein. Diverse expression of selected cytokines and proteinases in synovial fluid obtained from osteoarthritic and healthy human knee joints.

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin differentiates early from end-stage disease. Osteoarthritis Cartilage 17 — Interleukin-1 function and role in rheumatic disease. Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions. Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production. A urine inhibitor of interleukin 1 activity that blocks ligand binding.

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  8. A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha. Molecular identification of a danger signal that alerts the immune system to dying cells. Genes Immun. A pilot study of IL-1 inhibition by anakinra in acute gout.

    IL-1 Is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Interleukin 1 trials in cancer patients: a review of the toxicity, antitumor and hematopoietic effects.

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